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Ction. In order for R137 antibody to block entry, it must interact with and block a critical site on the ectodomain of virion associated gH-gL. In order for the soluble protein to block infection, it has to compete with virion associated gH-gL for a critical step, and this might not be seen if there is a marked difference in affinity between the soluble form and the virion-associated form of gH-gL

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